2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P1260A
    FSLLRY-NH2 TFA 99.74%
    FSLLRY-NH2 TFA is a protease-activated receptor 2 (PAR2) inhibitor.
    FSLLRY-NH2 TFA
  • HY-P1594A
    Dynorphin A (1-10) (TFA)
    Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) (TFA) also blocks NMDA-activated current with an IC50 of 42.0 μM.
    Dynorphin A (1-10) (TFA)
  • HY-P1675A
    Acetyl-PHF6 amide TFA
    Acetyl-PHF6 amide TFA (AcPHF6 TFA) is a tau derived hexapeptide.
    Acetyl-PHF6 amide TFA
  • HY-Y0966S
    Glycine-15N 7299-33-4 ≥98.0%
    Glycine-15N is the 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
    Glycine-15N
  • HY-101884A
    Biotinylated-D-lysine TFA 99.32%
    Biotinylated-D-lysine TFA is a conjugate of L-biotin and D-lysine, where the carboxylate of L-biotin is coupled with the ϵ-amine of D-lysine via a secondary amide bond. Biotinylated-D-lysine TFA is an isomer of the neuroanatomical tracer Biocyte.
    Biotinylated-D-lysine TFA
  • HY-103138A
    (Rac)-WAY-161503 75704-24-4 98.49%
    (Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects.
    (Rac)-WAY-161503
  • HY-136181A
    YNT-185 1804978-81-1 98.36%
    YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models.
    YNT-185
  • HY-B1184AR
    (S)-Mephenytoin (Standard) 70989-04-7
    (S)-Mephenytoin (Standard) is the analytical standard of (S)-Mephenytoin. This product is intended for research and analytical applications. (S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsive agent. (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism.
    (S)-Mephenytoin (Standard)
  • HY-B1618S1
    Corticosterone-d4 2243253-91-8 ≥98.0%
    Corticosterone-d4 is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
    Corticosterone-d4
  • HY-N0473S8
    L-Tyrosine-d2 72963-27-0 ≥99.0%
    L-Tyrosine-d2 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-d2
  • HY-W345510
    Opiorphin 864084-88-8 98.83%
    Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission.
    Opiorphin
  • HY-121883S3
    Lignoceric acid-d4-1 1219794-59-8 ≥98.0%
    Lignoceric acid-d4-11 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research.
    Lignoceric acid-d4-1
  • HY-W013636R
    2-Ketoglutaric acid (Standard) 328-50-7 99.52%
    2-Ketoglutaric acid (Standard) (Alpha-Ketoglutaric acid (Standard)) is the analytical standard of 2-Ketoglutaric acid (HY-W013636). This product is intended for research and analytical applications. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM).
    2-Ketoglutaric acid (Standard)
  • HY-17456
    Omberacetam 157115-85-0 99.86%
    Omberacetam (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.
    Omberacetam
  • HY-70068
    SB-408124 288150-92-5 98.27%
    SB-408124 is a non-peptide OX1 receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 exhibits 50-fold selectivity over OX2 receptor.
    SB-408124
  • HY-B0262
    Methocarbamol 532-03-6 99.80%
    Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research.
    Methocarbamol
  • HY-B1382
    Pempidine 79-55-0 99.83%
    Pempidine (1,2,2,6,6-Pentamethylpiperidine) is an orally active ganglionic blocking agent used in the treatment of hypertension-related conditions.
    Pempidine
  • HY-Y1673
    Potassium bromide, 99% 7758-02-3 ≥99.0%
    Potassium bromide, 99% is a salt, widely used as an anticonvulsant and a sedative. Potassium bromide is a redox reagent that can be used to remove peripheral membrane proteins in molecular biology.
    Potassium bromide, 99%
  • HY-128111
    ASN02563583 483283-39-2 99.21%
    ASN02563583, a compound that regulates the activity of the GPR17 receptor, has a IC50 value of 0.64 nM in [35S]GTPγS binding assay. ASN02563583 can be used in the study of neurological diseases.
    ASN02563583
  • HY-U00433
    JMV 2959 925238-89-7 99.91%
    JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM.
    JMV 2959
Cat. No. Product Name / Synonyms Application Reactivity